On The Pen: The Weekly Dose
Dave Knapp brings you your weekly dose of everything in the news about incretin mimetic, diabetes and obesity therapies, like Zepbound and Mounjaro, Ozempic and Wegovy, and even investigational treatments like CagriSema and Retatrutide!
On The Pen: The Weekly Dose
On The Pen: The Weekly Dose 6.4.24
https://ro.co/weight-loss/supply-tracker
https://www.youtube.com/watch?v=mL_krAas70k
Novo Nordisk Advertising:
- Novo Nordisk launches new advertising campaign "The Power of Wegovy"
- This advertisement includes the new indication for reduction of cardiovascular risk
- For 2023, the #5 advertising spend for a drug was Rybelsus at $191 million. The #6 advertising spend was Ozempic at $187.4 million (increase of 6% from 2022). More than 40% of the 2023 ad spend for Ozempic went to online video platforms (i.e. social media like youtube)
- Link: https://www.youtube.com/watch?v=dhretLXYkZ4
Structure Therapeutics GSBR-1290
- GSBR-1290 is a small molecule GLP-1 pill
- In a 12-week phase 2 clinical study, a tablet formulation of GSBR-1290 had a weight-loss of 6.9%. This is comparable to Eli Lilly's phase 2 results for olforglipron
- At Week 12, 67% of GSBR-1290 treated participants achieved ≥6% weight loss and 33% achieved ≥ 10% weight loss, compared to 0% for placebo
- Also developing next generation combination GLP-1 candidates together with GIP, amylin, glucagon and apelin oral small molecules
- Link (Madison Muller): https://www.bloomberg.com/news/articles/2024-06-03/structure-reports-early-oral-weight-loss-drug-data-adding-allure
Elon musk tweet:
- Elon Musk tweeted: Just make a lot of Ozempic/Mounjaro. It’s not inherently expensive. The health benefits of reducing obesity far exceed the downside of GLP-1 inhibitors. We evolved under starving conditions and now make food that is plentiful and delicious. Whether that food is “processed” does matter, but is not a game changer
- This tweet has currently been seen 325,500 times
Shanghai Stem Cell Type 2 Diabetes Treatment
https://www.scmp.com/news/china/science/article/3263878/chinese-scientists-report-world-first-they-cure-patients-diabetes-cell-therapy
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